Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes
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چکیده
منابع مشابه
Regulation of Aquaporin Water Permeability
Aquaporins facilitate the diffusion of water across cell membranes. We previously showed that acid pH or low Ca 2 increase the water permeability of bovine AQP0 expressed in Xenopus oocytes. We now show that external histidines in loops A and C mediate the pH dependence. Furthermore, the position of histidines in different members of the aquaporin family can “tune” the pH sensitivity toward alk...
متن کاملNovel variants in human Aquaporin-4 reduce cellular water permeability.
Cerebral edema contributes significantly to morbidity and mortality after brain injury and stroke. Aquaporin-4 (AQP4), a water channel expressed in astrocytes, plays a key role in brain water homeostasis. Genetic variants in other aquaporin family members have been associated with disease phenotypes. However, in human AQP4, only one non-synonymous single-nucleotide polymorphism (nsSNP) has been...
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| We have reproduced the process of protein transport across and of protein integration into the mammalian endoplasmic reticulum membrane by the use of proteoliposomes reconstituted from pure phospholipids and purified membrane proteins. The transport of some proteins requires only two membrane protein complexes: the signal recognition particle receptor, needed for targeting of a nascent chain ...
متن کاملMercury increases water permeability of a plant aquaporin through a non-cysteine-related mechanism.
Water transport across cellular membranes is mediated by a family of membrane proteins known as AQPs (aquaporins). AQPs were first discovered on the basis of their ability to be inhibited by mercurial compounds, an experiment which has followed the AQP field ever since. Although mercury inhibition is most common, many AQPs are mercury insensitive. In plants, regulation of AQPs is important in o...
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Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial cells. Several types of posttranslational modifications are clearly involved in controlling the distribution of AQP2 between intracellular vesicles and the apical plasma membrane. Little is known, however, about the protein interactions that ...
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ژورنال
عنوان ژورنال: Biology of the Cell
سال: 2008
ISSN: 0248-4900
DOI: 10.1111/j.1768-322x.2008.tb01301.x